AHCODA-DB

Experiment name: Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model. (Kramvis 2014)
LSID: http://syli.cz/urn:lsid:public.sylics.com:experiment:8D2E-9EE7-9674

TreatmentAmountAdministration routeAdministration time


Treatment info:
Order of behavioural testing
PhenoTyper Spontaneous Behaviour
PhenoTyper Appetitive Conditioning
PhenoTyper Avoidance Learning

Published in Frontiers in Behavioral Neuroscience 2013: http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00172/full

Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model.
Ioannis Kramvis (1,2), Huibert D. Mansvelder (1), Maarten Loos (2,3) and Rhiannon Meredith (1)
1) Department of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, Netherlands, 2) Sylics (Synaptologics BV), Amsterdam, Netherlands, 3) Department of Molecular and Cellular Neurobiology, Centre for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, Netherlands

Abstract
Attentional deficits and executive function impairments are common to many neurodevelopmental disorders of intellectual disability and autism, including Fragile X syndrome (FXS). In the knockout mouse model for FXS, significant changes in synaptic plasticity and connectivity are found in the prefrontal cortex (PFC)-a prominent region for attentional processing and executive control. Given these alterations in PFC synaptic function, we tested whether adult Fragile X knockout mice exhibited corresponding impairments in inhibitory control, perseveration, and sustained attention. Furthermore, we investigated individual performance during attentional rule acquisition. Using the 5-choice serial reaction time task, our results show no impairments in inhibitory control and sustained attention. Fragile X knockout mice exhibited enhanced levels of correct and incorrect responding, as well as perseveration of responding during initial phases of rule acquisition, that normalized with training. For both knockout and wild type mice, pharmacological attenuation of metabotropic glutamate receptor 5 signaling did not affect response accuracy but reduced impulsive responses and increased omission errors. Upon rule reversal, Fragile X knockout mice made more correct and incorrect responses, similar to the initial phases of rule acquisition. Analogous to heightened activity upon novel rule acquisition, Fragile X knockout mice were transiently hyperactive in both a novel open field (OF) arena and novel home cage. Hyperactivity ceased with familiarization to the environment. Our findings demonstrate normal inhibitory control and sustained attention but heightened perseveration, responding, and hyperactivity during novel rule acquisition and during exposure to novel environments in Fragile X knockout mice. We therefore provide evidence for subtle but significant differences in the processing of novel stimuli in the mouse model for the FXS.


In this manuscript: Home-cage activity data of Fragile X knockout mice
Distance covered in novel home-cage was greater in young adult Fragile X knockout mice during the first two dark-cycles but not during the third dark-cycle: http://syli.cz/v



Mouse info:
Mouse ID Strain Coat color Genotype Ear tag Internal ID Sex Date of Birth Sub experiment 1 Sub experiment 2 Sub experiment 3
PH04252 Fmr1 unknown hom male 00-00-0000
PH04253 Fmr1 unknown hom male 00-00-0000
PH04254 Fmr1 unknown WT male 00-00-0000
PH04255 Fmr1 unknown hom male 00-00-0000
PH04256 Fmr1 unknown hom male 00-00-0000
PH04257 Fmr1 unknown WT male 00-00-0000
PH04258 Fmr1 unknown hom male 00-00-0000
PH04259 Fmr1 unknown WT male 00-00-0000
PH04338 Fmr1 unknown WT male 00-00-0000
PH04339 Fmr1 unknown WT male 00-00-0000
PH04340 Fmr1 unknown hom male 00-00-0000
PH04341 Fmr1 unknown hom male 00-00-0000
PH04342 Fmr1 unknown hom male 00-00-0000
PH04343 Fmr1 unknown WT male 00-00-0000
PH04344 Fmr1 unknown hom male 00-00-0000
PH04345 Fmr1 unknown hom male 00-00-0000
PH04346 Fmr1 unknown WT male 00-00-0000
PH04347 Fmr1 unknown WT male 00-00-0000
PH04348 Fmr1 unknown WT male 00-00-0000
PH04349 Fmr1 unknown WT male 00-00-0000
PH04350 Fmr1 unknown WT male 00-00-0000
PH04351 Fmr1 unknown WT male 00-00-0000
PH04749 Fmr1 unknown hom male 00-00-0000
PH04750 Fmr1 unknown hom male 00-00-0000
PH04751 Fmr1 unknown WT male 00-00-0000
PH04752 Fmr1 unknown WT male 00-00-0000
PH04753 Fmr1 unknown WT male 00-00-0000
PH04754 Fmr1 unknown WT male 00-00-0000
PH04755 Fmr1 unknown hom male 00-00-0000
PH04756 Fmr1 unknown hom male 00-00-0000
PH04757 Fmr1 unknown hom male 00-00-0000
PH04758 Fmr1 unknown WT male 00-00-0000
PH04759 Fmr1 unknown WT male 00-00-0000
PH04760 Fmr1 unknown hom male 00-00-0000
PH04761 Fmr1 unknown hom male 00-00-0000
PH04762 Fmr1 unknown hom male 00-00-0000
PH04763 Fmr1 unknown hom male 00-00-0000
PH04764 Fmr1 unknown hom male 00-00-0000
PH04765 Fmr1 unknown WT male 00-00-0000
PH04766 Fmr1 unknown WT male 00-00-0000
PH04767 Fmr1 unknown hom male 00-00-0000
PH04768 Fmr1 unknown hom male 00-00-0000
PH04769 Fmr1 unknown hom male 00-00-0000
PH04770 Fmr1 unknown hom male 00-00-0000
PH04771 Fmr1 unknown WT male 00-00-0000
PH04772 Fmr1 unknown WT male 00-00-0000
PH04773 Fmr1 unknown WT male 00-00-0000
PH04774 Fmr1 unknown hom male 00-00-0000
PH04775 Fmr1 unknown hom male 00-00-0000
PH04776 Fmr1 unknown WT male 00-00-0000
PH04777 Fmr1 unknown WT male 00-00-0000
PH04778 Fmr1 unknown WT male 00-00-0000
PH04779 Fmr1 unknown WT male 00-00-0000
PH04780 Fmr1 unknown WT male 00-00-0000