AHCODA-DB

Experiment name: Cognitive flexibility deficits in a mouse model for the absence of full-length dystrophin. (Remmelink 2016)
LSID: http://syli.cz/urn:lsid:public.sylics.com:experiment:4273-97E7-39D6

TreatmentAmountAdministration routeAdministration time


Treatment info:
Order of behavioural testing
PhenoTyper Spontaneous Behaviour
PhenoTyper Initial Discrimination and Reversal Learning (CognitionWall)

Published in Genes, Brain and Behavior 2016
http://doi.wiley.com/10.1111/gbb.12301

Cognitive flexibility deficits in a mouse model for the absence of full-length dystrophin
E. Remmelink, A. Aartsma-Rus, A. B. Smit, M. Verhage, M. Loos, M. van Putten

Abstract
Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder, caused by mutations in the DMD gene and the resulting lack of dystrophin. The DMD gene has seven promoters, giving rise to multiple full-length and shorter isoforms. Besides the expression of dystrophin in muscles, the majority of dystrophin isoforms is expressed in brain and dystrophinopathy can lead to cognitive deficits, including intellectual impairments and deficits in executive function. In contrast to the muscle pathology, the impact of the lack of dystrophin on the brain is not very well studied. Here, we study the behavioral consequences of a lack of full-length dystrophin isoforms in mdx mice, particularly with regard to domains of executive functions and anxiety. We observed a deficit in cognitive flexibility in mdx mice in the absence of motor dysfunction or general learning impairments using two independent behavioral tests. In addition, increased anxiety was observed, but its expression depended on the context. Overall, these results suggest that the absence of full-length dystrophin in mice has specific behavioral effects that compare well to deficits observed in DMD patients.

Mouse info:
Mouse ID Strain Coat color Genotype Ear tag Internal ID Sex Date of Birth Sub experiment 1 Sub experiment 2 Sub experiment 3
PH07185 MDX black WT RL 7240492 male 04-04-2013
PH07186 MDX black WT R 7240484 male 06-04-2013
PH07187 MDX black WT L 7240485 male 06-04-2013
PH07188 MDX black WT RL 7240486 male 06-04-2013
PH07189 MDX black WT RR 7240487 male 06-04-2013
PH07190 MDX black WT R 7241075 male 12-04-2013
PH07191 MDX black WT L 7241076 male 12-04-2013
PH07192 MDX black hom R 9072886 male 13-04-2013
PH07193 MDX black hom L 9072899 male 18-04-2013
PH07194 MDX black hom RL 9072900 male 18-04-2013
PH07195 MDX black hom RR 9072901 male 18-04-2013
PH07196 MDX black hom LL 9072902 male 18-04-2013
PH07197 MDX black hom R 9072880 male 19-04-2013
PH07198 MDX black hom L 9072881 male 19-04-2013
PH07199 MDX black hom RR 9072883 male 19-04-2013
PH07200 MDX black WT RL 7242602 male 27-04-2013
PH07201 MDX black WT RR 7242603 male 27-04-2013
PH07202 MDX black hom RL 9073464 male 27-04-2013
PH07203 MDX black hom LL 9073466 male 27-04-2013
PH07204 MDX black hom RRL 9073467 male 27-04-2013
PH07205 MDX black WT R 7243360 male 02-05-2013
PH07206 MDX black WT L 7243355 male 04-05-2013
PH07207 MDX black hom L 9073713 male 12-05-2013
PH07208 MDX black hom L 9073722 male 12-05-2013
PH07340 MDX black WT RL 7242602 male 27-04-2013
PH07341 MDX black WT RR 7242603 male 27-04-2013
PH07342 MDX black hom RL 9073464 male 27-04-2013
PH07343 MDX black hom LL 9073466 male 27-04-2013
PH07344 MDX black hom RRL 9073467 male 27-04-2013
PH07346 MDX black WT RL 7240492 male 04-04-2013
PH07347 MDX black WT R 7240484 male 06-04-2013
PH07348 MDX black WT L 7240485 male 06-04-2013
PH07349 MDX black WT RL 7240486 male 06-04-2013
PH07350 MDX black WT RR 7240487 male 06-04-2013
PH07351 MDX black WT R 7241075 male 12-04-2013
PH07352 MDX black WT L 7241076 male 12-04-2013
PH07353 MDX black hom R 9072886 male 13-04-2013
PH07354 MDX black hom L 9072899 male 18-04-2013
PH07355 MDX black hom RL 9072900 male 18-04-2013
PH07356 MDX black hom RR 9072901 male 18-04-2013
PH07357 MDX black hom LL 9072902 male 18-04-2013
PH07358 MDX black hom R 9072880 male 19-04-2013
PH07359 MDX black hom L 9072881 male 19-04-2013
PH07360 MDX black hom RR 9072883 male 19-04-2013
PH07361 MDX black WT R 7243360 male 02-05-2013
PH07362 MDX black WT L 7243355 male 04-05-2013
PH07363 MDX black hom L 9073713 male 12-05-2013
PH07364 MDX black hom L 9073722 male 12-05-2013
PH07433 MDX black WT RL 7242602 male 27-04-2013
PH07434 MDX black WT RR 7242603 male 27-04-2013
PH07435 MDX black hom RL 9073464 male 27-04-2013
PH07436 MDX black hom LL 9073466 male 27-04-2013
PH07437 MDX black hom RRL 9073467 male 27-04-2013
PH07439 MDX black WT RL 7240492 male 04-04-2013
PH07440 MDX black WT R 7240484 male 06-04-2013
PH07441 MDX black WT L 7240485 male 06-04-2013
PH07442 MDX black WT RL 7240486 male 06-04-2013
PH07443 MDX black WT RR 7240487 male 06-04-2013
PH07444 MDX black WT R 7241075 male 12-04-2013
PH07445 MDX black WT L 7241076 male 12-04-2013
PH07446 MDX black hom R 9072886 male 13-04-2013
PH07447 MDX black hom L 9072899 male 18-04-2013
PH07448 MDX black hom RL 9072900 male 18-04-2013
PH07449 MDX black hom RR 9072901 male 18-04-2013
PH07450 MDX black hom LL 9072902 male 18-04-2013
PH07451 MDX black hom R 9072880 male 19-04-2013
PH07452 MDX black hom L 9072881 male 19-04-2013
PH07453 MDX black hom RR 9072883 male 19-04-2013
PH07454 MDX black WT R 7243360 male 02-05-2013
PH07455 MDX black WT L 7243355 male 04-05-2013
PH07456 MDX black hom L 9073713 male 12-05-2013
PH07457 MDX black hom L 9073722 male 12-05-2013