Neurological score (long-term)
LSID: http://syli.cz/urn:lsid:public.sylics.com:conventionaltest:3982-B68E-B7ADMaterials and Methods
Mice were singly housed on sawdust in standard Makrolon type II cages enriched with cardboard nesting material for at least one week prior to experiments, with water and food ad libitum (7:00/19:00 lights on/off; providing an abrupt phase transition).
Associated Mammalian Phenotype Ontologies (MGI)
- MP:0000745 tremors
Neurological score
General wellbeing of the mice was assessed by observation of a number of characteristics.
Scoring:
0) Full extension of hind legs away from lateral midline when mouse is suspended by its tail, and mouse can hold this for 2 seconds, suspended 2–3 times.
1) Collapse or partial collapse of leg extension towards lateral midline (weakness) or trembling of hind legs during tail suspension.
2) Toes curl under at least twice during walking of 12 inches, or any part of foot is dragging along cage bottom/table (food provided in cage floor).
3) Rigid paralysis or minimal joint movement, foot not being used for forward motion.
4) Mouse cannot right itself within 30 seconds from either side.
Parameter information
| Parameter name | Units |
| *Neurological score | Score |