LSID: http://syli.cz/urn:lsid:public.sylics.com:experiment:8D2E-9EE7-9674
| Treatment | Amount | Administration route | Administration time |
Treatment info:
Order of behavioural testing
PhenoTyper Spontaneous Behaviour
PhenoTyper Appetitive Conditioning
PhenoTyper Avoidance Learning
Published in Frontiers in Behavioral Neuroscience 2013: http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00172/full
Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model.
Ioannis Kramvis (1,2), Huibert D. Mansvelder (1), Maarten Loos (2,3) and Rhiannon Meredith (1)
1) Department of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, Netherlands, 2) Sylics (Synaptologics BV), Amsterdam, Netherlands, 3) Department of Molecular and Cellular Neurobiology, Centre for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, Netherlands
Abstract
Attentional deficits and executive function impairments are common to many neurodevelopmental disorders of intellectual disability and autism, including Fragile X syndrome (FXS). In the knockout mouse model for FXS, significant changes in synaptic plasticity and connectivity are found in the prefrontal cortex (PFC)-a prominent region for attentional processing and executive control. Given these alterations in PFC synaptic function, we tested whether adult Fragile X knockout mice exhibited corresponding impairments in inhibitory control, perseveration, and sustained attention. Furthermore, we investigated individual performance during attentional rule acquisition. Using the 5-choice serial reaction time task, our results show no impairments in inhibitory control and sustained attention. Fragile X knockout mice exhibited enhanced levels of correct and incorrect responding, as well as perseveration of responding during initial phases of rule acquisition, that normalized with training. For both knockout and wild type mice, pharmacological attenuation of metabotropic glutamate receptor 5 signaling did not affect response accuracy but reduced impulsive responses and increased omission errors. Upon rule reversal, Fragile X knockout mice made more correct and incorrect responses, similar to the initial phases of rule acquisition. Analogous to heightened activity upon novel rule acquisition, Fragile X knockout mice were transiently hyperactive in both a novel open field (OF) arena and novel home cage. Hyperactivity ceased with familiarization to the environment. Our findings demonstrate normal inhibitory control and sustained attention but heightened perseveration, responding, and hyperactivity during novel rule acquisition and during exposure to novel environments in Fragile X knockout mice. We therefore provide evidence for subtle but significant differences in the processing of novel stimuli in the mouse model for the FXS.
In this manuscript: Home-cage activity data of Fragile X knockout mice
Distance covered in novel home-cage was greater in young adult Fragile X knockout mice during the first two dark-cycles but not during the third dark-cycle: http://syli.cz/v
Mouse info:
| Mouse ID | Strain | Coat color | Genotype | Ear tag | Internal ID | Sex | Date of Birth | Sub experiment 1 | Sub experiment 2 | Sub experiment 3 |
| PH04252 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04253 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04254 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04255 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04256 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04257 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04258 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04259 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04338 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04339 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04340 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04341 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04342 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04343 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04344 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04345 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04346 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04347 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04348 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04349 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04350 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04351 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04749 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04750 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04751 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04752 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04753 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04754 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04755 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04756 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04757 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04758 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04759 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04760 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04761 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04762 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04763 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04764 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04765 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04766 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04767 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04768 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04769 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04770 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04771 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04772 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04773 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04774 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04775 | Fmr1 | unknown | hom | male | 00-00-0000 | |||||
| PH04776 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04777 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04778 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04779 | Fmr1 | unknown | WT | male | 00-00-0000 | |||||
| PH04780 | Fmr1 | unknown | WT | male | 00-00-0000 |