AHCODA-DB

Experiment name: SOD1 reference
LSID: http://syli.cz/urn:lsid:public.sylics.com:experiment:4273-G72E-9D65

TreatmentAmountAdministration routeAdministration time
06wk
12wk
20wk


Treatment info:
Male and female SOD1 mice (SOD1-G93A) on C57BL/6J background were longitudinally followed in automated home-cages (PhenoTyper, Noldus IT) and data was analyzed using AHCODA (Sylics). The analysis of spontaneous behavior in the PhenoTyper extracted 20 key parameters, as explained in detail here:http://www.sylics.com/bioinformatics/testing-protocols/spontaneous-behaviour/

Several spontaneous behavior parameters detected motor function impaired in the SOD1 model. The maximum velocity of the 10% fastest movement segments decreases with age (see here: http://syli.cz/G). Also, the number of times a mouse jumps on top of the shelter decreased with age (see here: http://syli.cz/H).

Interestingly, general during the dark phase is affected to a lesser extent (see: http://syli.cz/J), suggesting that simply looking at activity in this model is less sensitive in comparison to the above parameters.


Mouse info:
Mouse ID Strain Coat color Genotype Ear tag Internal ID Sex Date of Birth Sub experiment 1 Sub experiment 2 Sub experiment 3
PH05894 SOD1(G93A) black mut R 222 female 18-12-2012 06wk
PH05896 SOD1(G93A) black mut RL 224 female 18-12-2012 06wk
PH05900 SOD1(G93A) black mut R 539 female 26-12-2012 06wk
PH05901 SOD1(G93A) black mut L 540 female 26-12-2012 06wk
PH06043 SOD1(G93A) black WT R 964 male 03-01-2013 06wk
PH06045 SOD1(G93A) black WT - 966 female 03-01-2013 06wk
PH06047 SOD1(G93A) black mut L 968 female 03-01-2013 06wk
PH06048 SOD1(G93A) black WT RL 969 female 03-01-2013 06wk
PH06049 SOD1(G93A) black WT - 1322 male 09-01-2013 06wk
PH06050 SOD1(G93A) black WT RR 1323 male 09-01-2013 06wk
PH06053 SOD1(G93A) black WT - 1326 female 09-01-2013 06wk
PH06054 SOD1(G93A) black WT R 1327 female 09-01-2013 06wk
PH06055 SOD1(G93A) black mut L 1328 female 09-01-2013 06wk
PH06056 SOD1(G93A) black mut RL 1329 female 09-01-2013 06wk
PH06058 SOD1(G93A) black WT R 1331 male 10-01-2013 06wk
PH06059 SOD1(G93A) black mut L 1332 male 10-01-2013 06wk
PH06060 SOD1(G93A) black WT RL 1333 male 10-01-2013 06wk
PH06064 SOD1(G93A) black mut - 1618 male 10-01-2013 06wk
PH06065 SOD1(G93A) black WT R 1619 male 10-01-2013 06wk
PH06066 SOD1(G93A) black mut L 1620 male 10-01-2013 06wk
PH06068 SOD1(G93A) black mut RR 1622 male 10-01-2013 06wk
PH06144 SOD1(G93A) black mut R 222 female 18-12-2012 12wk
PH06146 SOD1(G93A) black mut RL 224 female 18-12-2012 12wk
PH06150 SOD1(G93A) black mut R 539 female 26-12-2012 12wk
PH06151 SOD1(G93A) black mut L 540 female 26-12-2012 12wk
PH06284 SOD1(G93A) black WT R 964 male 03-01-2013 12wk
PH06286 SOD1(G93A) black WT - 966 female 03-01-2013 12wk
PH06288 SOD1(G93A) black mut L 968 female 03-01-2013 12wk
PH06289 SOD1(G93A) black WT RL 969 female 03-01-2013 12wk
PH06290 SOD1(G93A) black WT - 1322 male 09-01-2013 12wk
PH06291 SOD1(G93A) black WT RR 1323 male 09-01-2013 12wk
PH06294 SOD1(G93A) black WT - 1326 female 09-01-2013 12wk
PH06295 SOD1(G93A) black WT R 1327 female 09-01-2013 12wk
PH06296 SOD1(G93A) black mut L 1328 female 09-01-2013 12wk
PH06297 SOD1(G93A) black mut RL 1329 female 09-01-2013 12wk
PH06299 SOD1(G93A) black WT R 1331 male 10-01-2013 12wk
PH06300 SOD1(G93A) black mut L 1332 male 10-01-2013 12wk
PH06301 SOD1(G93A) black WT RL 1333 male 10-01-2013 12wk
PH06305 SOD1(G93A) black mut - 1618 male 10-01-2013 12wk
PH06306 SOD1(G93A) black WT R 1619 male 10-01-2013 12wk
PH06307 SOD1(G93A) black mut L 1620 male 10-01-2013 12wk
PH06309 SOD1(G93A) black mut RR 1622 male 10-01-2013 12wk
PH06601 SOD1(G93A) black WT - 6316 male 26-03-2013 06wk
PH06602 SOD1(G93A) black mut RL 6317 male 26-03-2013 06wk
PH06608 SOD1(G93A) black WT R 6323 male 26-03-2013 06wk
PH06611 SOD1(G93A) black WT RR 6326 male 26-03-2013 06wk
PH06612 SOD1(G93A) black WT - 6327 male 27-03-2013 06wk
PH06614 SOD1(G93A) black WT - 6329 female 26-03-2013 06wk
PH06617 SOD1(G93A) black WT RL 6332 female 26-03-2013 06wk
PH06619 SOD1(G93A) black WT LL 6334 female 26-03-2013 06wk
PH06624 SOD1(G93A) black mut RR 6339 female 26-03-2013 06wk
PH06625 SOD1(G93A) black WT LL 6340 female 26-03-2013 06wk
PH06651 SOD1(G93A) black WT - 6765 male 28-03-2013 06wk
PH06655 SOD1(G93A) black mut RR 6769 male 28-03-2013 06wk
PH06656 SOD1(G93A) black mut LL 6770 male 28-03-2013 06wk
PH06661 SOD1(G93A) black mut RR 6775 male 28-03-2013 06wk
PH06663 SOD1(G93A) black WT - 6777 male 28-03-2013 06wk
PH06666 SOD1(G93A) black WT RL 6780 male 28-03-2013 06wk
PH06668 SOD1(G93A) black mut R 6782 female 28-03-2013 06wk
PH06669 SOD1(G93A) black mut L 6783 female 28-03-2013 06wk
PH06673 SOD1(G93A) black mut - 6787 female 28-03-2013 06wk
PH06675 SOD1(G93A) black WT L 6789 female 28-03-2013 06wk
PH06676 SOD1(G93A) black mut RL 6790 female 28-03-2013 06wk
PH06685 SOD1(G93A) black WT - 6800 female 28-03-2013 06wk
PH06686 SOD1(G93A) black WT R 6801 female 28-03-2013 06wk
PH06687 SOD1(G93A) black mut L 6802 female 28-03-2013 06wk
PH06688 SOD1(G93A) black WT RL 6803 female 28-03-2013 06wk
PH06759 SOD1(G93A) black WT R 964 male 03-01-2013 20wk
PH06761 SOD1(G93A) black WT - 966 female 03-01-2013 20wk
PH06763 SOD1(G93A) black mut L 968 female 03-01-2013 20wk
PH06764 SOD1(G93A) black WT RL 969 female 03-01-2013 20wk
PH06765 SOD1(G93A) black WT - 1322 male 09-01-2013 20wk
PH06766 SOD1(G93A) black WT RR 1323 male 09-01-2013 20wk
PH06769 SOD1(G93A) black WT - 1326 female 09-01-2013 20wk
PH06770 SOD1(G93A) black WT R 1327 female 09-01-2013 20wk
PH06771 SOD1(G93A) black mut L 1328 female 09-01-2013 20wk
PH06772 SOD1(G93A) black mut RL 1329 female 09-01-2013 20wk
PH06774 SOD1(G93A) black WT R 1331 male 10-01-2013 20wk
PH06775 SOD1(G93A) black mut L 1332 male 10-01-2013 20wk
PH06776 SOD1(G93A) black WT RL 1333 male 10-01-2013 20wk
PH06780 SOD1(G93A) black mut - 1618 male 10-01-2013 20wk
PH06781 SOD1(G93A) black WT R 1619 male 10-01-2013 20wk
PH06782 SOD1(G93A) black mut L 1620 male 10-01-2013 20wk
PH06784 SOD1(G93A) black mut RR 1622 male 10-01-2013 20wk
PH06789 SOD1(G93A) black WT - 6316 male 26-03-2013 12wk
PH06790 SOD1(G93A) black mut RL 6317 male 26-03-2013 12wk
PH06796 SOD1(G93A) black WT R 6323 male 26-03-2013 12wk
PH06799 SOD1(G93A) black WT RR 6326 male 26-03-2013 12wk
PH06800 SOD1(G93A) black WT - 6327 male 27-03-2013 12wk
PH06802 SOD1(G93A) black WT - 6329 female 26-03-2013 12wk
PH06805 SOD1(G93A) black WT RL 6332 female 26-03-2013 12wk
PH06807 SOD1(G93A) black WT LL 6334 female 26-03-2013 12wk
PH06812 SOD1(G93A) black mut RR 6339 female 26-03-2013 12wk
PH06813 SOD1(G93A) black WT LL 6340 female 26-03-2013 12wk
PH06814 SOD1(G93A) black WT - 6765 male 28-03-2013 12wk
PH06816 SOD1(G93A) black mut RR 6769 male 28-03-2013 12wk
PH06817 SOD1(G93A) black mut LL 6770 male 28-03-2013 12wk
PH06821 SOD1(G93A) black mut RR 6775 male 28-03-2013 12wk
PH06822 SOD1(G93A) black WT - 6777 male 28-03-2013 12wk
PH06825 SOD1(G93A) black WT RL 6780 male 28-03-2013 12wk
PH06826 SOD1(G93A) black mut R 6782 female 28-03-2013 12wk
PH06827 SOD1(G93A) black mut L 6783 female 28-03-2013 12wk
PH06828 SOD1(G93A) black mut - 6787 female 28-03-2013 12wk
PH06830 SOD1(G93A) black WT L 6789 female 28-03-2013 12wk
PH06831 SOD1(G93A) black mut RL 6790 female 28-03-2013 12wk
PH06840 SOD1(G93A) black WT - 6800 female 28-03-2013 12wk
PH06841 SOD1(G93A) black WT R 6801 female 28-03-2013 12wk
PH06842 SOD1(G93A) black mut L 6802 female 28-03-2013 12wk
PH06843 SOD1(G93A) black WT RL 6803 female 28-03-2013 12wk
PH06845 SOD1(G93A) black WT - 6316 male 26-03-2013 20wk
PH06846 SOD1(G93A) black mut RL 6317 male 26-03-2013 20wk
PH06852 SOD1(G93A) black WT R 6323 male 26-03-2013 20wk
PH06855 SOD1(G93A) black WT RR 6326 male 26-03-2013 20wk
PH06856 SOD1(G93A) black WT - 6327 male 27-03-2013 20wk
PH06858 SOD1(G93A) black WT - 6329 female 26-03-2013 20wk
PH06861 SOD1(G93A) black WT RL 6332 female 26-03-2013 20wk
PH06863 SOD1(G93A) black WT LL 6334 female 26-03-2013 20wk
PH06868 SOD1(G93A) black mut RR 6339 female 26-03-2013 20wk
PH06869 SOD1(G93A) black WT LL 6340 female 26-03-2013 20wk
PH06870 SOD1(G93A) black WT - 6765 male 28-03-2013 20wk
PH06872 SOD1(G93A) black mut RR 6769 male 28-03-2013 20wk
PH06873 SOD1(G93A) black mut LL 6770 male 28-03-2013 20wk
PH06877 SOD1(G93A) black mut RR 6775 male 28-03-2013 20wk
PH06878 SOD1(G93A) black WT - 6777 male 28-03-2013 20wk
PH06881 SOD1(G93A) black WT RL 6780 male 28-03-2013 20wk
PH06882 SOD1(G93A) black mut R 6782 female 28-03-2013 20wk
PH06883 SOD1(G93A) black mut L 6783 female 28-03-2013 20wk
PH06884 SOD1(G93A) black mut - 6787 female 28-03-2013 20wk
PH06886 SOD1(G93A) black WT L 6789 female 28-03-2013 20wk
PH06887 SOD1(G93A) black mut RL 6790 female 28-03-2013 20wk
PH06896 SOD1(G93A) black WT - 6800 female 28-03-2013 20wk
PH06897 SOD1(G93A) black WT R 6801 female 28-03-2013 20wk
PH06898 SOD1(G93A) black mut L 6802 female 28-03-2013 20wk
PH06899 SOD1(G93A) black WT RL 6803 female 28-03-2013 20wk
PH07533 SOD1(G93A) black mut - 526 male 18-06-2013 06wk
PH07535 SOD1(G93A) black mut L 528 male 18-06-2013 06wk
PH07537 SOD1(G93A) black mut RR 530 male 18-06-2013 06wk
PH07539 SOD1(G93A) black WT - 532 female 18-06-2013 06wk
PH07540 SOD1(G93A) black mut L 534 female 18-06-2013 06wk
PH07542 SOD1(G93A) black WT RR 536 female 18-06-2013 06wk
PH07950 SOD1(G93A) black mut - 526 male 18-06-2013 20wk
PH07952 SOD1(G93A) black mut L 528 male 18-06-2013 20wk
PH07954 SOD1(G93A) black mut RR 530 male 18-06-2013 20wk
PH07956 SOD1(G93A) black WT - 532 female 18-06-2013 20wk
PH07957 SOD1(G93A) black mut L 534 female 18-06-2013 20wk
PH07959 SOD1(G93A) black WT RR 536 female 18-06-2013 20wk