AHCODA-DB

Experiment name: 5xFAD (reference)
LSID: http://syli.cz/urn:lsid:public.sylics.com:experiment:E257-G38E-9A46

TreatmentAmountAdministration routeAdministration time
20wks


Treatment info:
Order of behavioural testing
PhenoTyper Spontaneous Behaviour
PhenoTyper Appetitive Conditioning
PhenoTyper Avoidance Learning

Nesting test
Fear Conditioning


Detailed information:
At 20 weeks of age, the5xFAD transgenic mouse model of Alzheimer's disease does not show large differences in activity in the automated home-cage environment. Two parameters of the key set of 20 spontaneous behavior parameters showed a significant difference. The short shelter visit threshold is lower in TG mice compared with WT mice. The mean activity duration in the light phase was significantly lower in TG mice. Besides these 2 parameters of the set of 20 key parameters, none of the 95 remaining parameters was significantly different except for the mean short shelter visit duration (highly correlated to the short shelter visit threshold), suggesting a highly specific effect on sheltering behavior in the mutant. It is tempting to speculate that the lower short shelter visits threshold relates to hippocampal dysfunction in this mouse, as evident from impaired nesting scores and the trend towards significant decrease in contextual fear conditioning of TG mice.

Mouse info:
Mouse ID Strain Coat color Genotype Ear tag Internal ID Sex Date of Birth Sub experiment 1 Sub experiment 2 Sub experiment 3
PH04176 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04178 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04181 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04182 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04184 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04186 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04187 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04190 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04192 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04194 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04195 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04196 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04197 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04198 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04199 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04200 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04202 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04203 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04206 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04207 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04209 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04210 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04213 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04215 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04216 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04218 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04221 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04224 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks
PH04226 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04229 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04233 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04234 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04236 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black hom male 00-00-0000 20wks
PH04238 5xFAD_APP(Sw_Fl_Lon)_PSEN1(M146L_L286V) black WT male 00-00-0000 20wks